Bayesian Optimal Phase II Randomized Clinical Trial Design with Delayed Outcomes

Documentation for package ‘DTEBOP2’ version 1.0.3

conduct	Computes the hazard ratio between post- and pre-separation periods, provides the 95% Bayesian credible interval, and makes a Go/No-Go decision based on the trial data. This function is intended for interim and final analyses in two-arm survival trials with delayed treatment effects.
event_fun	Return expected event number at interim analysis and final analysis.
Experimental	Nivolumab KM data used for reconstructing PFS KM curve
generate_pe	Generate event times from a piecewise exponential distribution.
get.optimal_2arm_piecewise	Obtain Optimal Design Parameters for DTE-BOP2 Design
getoc_2arm_piecewise	Compute Operating Characteristics for Two-Arm Piecewise Exponential Designs
rtrunc_gamma	Generate Random Variables from a Truncated Gamma Distribution.
SOC	Docetaxel KM data used for reconstructing PFS KM curve
trunc_gamma_para	Estimate Shape and Scale Parameters for Truncated Gamma Distribution
TTOT_fun	Compute the Total Time-on-Test (TTOT) Statistic
Two_stage_sample_size	Calculate Sample Sizes for a Two-Stage Trial Design.